Genetic polymorphisms in DNA double-strand break repair genes XRCC5 , XRCC6 and susceptibility to hepatocellular carcinoma
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چکیده
منابع مشابه
Genetic polymorphisms in DNA double-strand break repair genes XRCC5, XRCC6 and susceptibility to hepatocellular carcinoma.
Environmental risk factors cause DNA damages. Imprecise DNA repair leads to chromosome aberrations, genome destabilization and hepatocarcinogenesis. Ku is a key DNA double-strand break repair protein. We hypothesized that the genetic variants in Ku subunits encoding genes, XRCC5/XRCC6, may contribute to hepatocellular carcinoma (HCC) susceptibility. We genotyped 13 common single nucleotide poly...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2011
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/bgr018